WhiteCoat Rants

Random thoughts about US Healthcare

When Is A Drug Allergy Not A Drug Allergy?

Posted by WhiteCoat on September 7, 2007

drug-allergy-list-2006_11.gif

So what do you do when a person has a “10 out of 10″ migraine and hands you this list?

We all know about patients who exhibit drug seeking behavior. One Seattle Times article showed that in 2003, some patients racked up substantial Medicaid bills for chronic pain complaints. Most patients visited multiple EDs (one patient hit 59 different hospitals in one year) and the costs were well over $20,000 for costs and prescriptions for most of the patients (one patient racked up $175,000 in costs in 2003 by visiting the ED 106 times in 365 days at 28 different hospitals for CHF and chest pain-related complaints). I don’t intend for this to single out Medicaid patients, but unfortunately, the data for Medicaid patients and their care is readily available. I’m sure that there are just as many bad apples in the insured and uninsured patient crowds as well.

Many patients aren’t drug seeking, though. And those patients warn physicians about allergies that aren’t really allergies. Penicillin “allergies” are notorious. When I ask the patient what their allergic reaction is, they tell me “My mom just always told me I was allergic. I must have had a reaction when I was a little kid.” That’s it. So what do you do?

I have to blame some physicians for not explaining to the patients that nausea, flushing, diarrhea, and bad tastes in the mouth are NOT allergies. They are adverse reactions. If you want to get better, sometimes you have to live with the adverse reactions.

The problem with “allergies that aren’t allergies” is that sometimes the “allergies” can prevent you from giving a medication that the patient really needs. What do you do with a patient who has allergies to multiple antibiotics and who comes in with septic shock? If you give the patient something they are “allergic to” and there is a bad outcome, you get sued. If you don’t give them an indicated antibiotic for the type of infection because of an “allergy” and there is a bad outcome, you can get sued, also.

A patient once handed me a list that contained 150 things to which she had allergic reactions, including “anything fermented,” yellow #5, oat smut, Rizopus, cocklebur, and Russian Thistle. Information overload! Danger, Will Robinson! Danger!

I can just see cross examination now: Well, Dr. Whitecoat, while it appears that this patient died from a heart attack, our expert has concluded that the true cause of death was an allergic reaction. Didn’t you think it was necessary to check to see that aspirin you administered was manufactured in a factory that also processes oat smut? How do you win?

The strangest allergy ever told to me was a little old lady who said she had an allergy to “water” — all except city water from the town she lived in and water from a “spring in a little town in northern France.” She brought a gallon jug of water from her home faucet whenever she came to the hospital. She always told everyone that if she drank any other kind of water, she “could die.” She always got IV fluid with no adverse reactions. Maybe the bags were manufactured in France. Always told myself I’d write about her some day.

Well, world, here it is.

22 Responses to “When Is A Drug Allergy Not A Drug Allergy?”

  1. PalMD said

    Loved the post. I once had a professor who said that allergies to more than 3 classes of medications correlated perfectly with psychiatric disease–humorous, but probably not exactly true. Many patients know that listing something as an allergy pretty much insures we won’t be able to give it to them. Sometimes I wonder why they just don’t hand me a note that says, “Im allergic to everything except dilaudid”.

  2. ERnursey said

    What in the heck is ‘oat smut’ and how exactly does one find out that they are allergic to it? I’ve always held the belief that more than 5 allergies = CRAZY

  3. scalpel said

    “So what do you do when a person has a “10 out of 10″ migraine and hands you this list?”

    Same as every other migraine patient….IV Toradol and Compazine! She forgot to list those.

  4. DementedM said

    I think I work with that migraine patient whose list you posted. You think it’s bad when they spend 4 or 8 hours in the ER? Try 40 hours a week.

    And do you think it’s possible for someone to take long term narcotics without suffering some kind of brain damage/psychosis? Because I’m starting to think no.

    M

  5. Christine said

    Oh, oh, oh, this drives me nuts too! People will do the same thing with food allergies. Some even have had skin testing done, and say that the testing doesn’t show the allergy, cause they’re only allergic once it’s digested. “Yes, I have allergies, I’m allergic to coffee, it makes my heart race.” Uhm, so don’t drink coffee, but you’re not allergic.

  6. Abby said

    Yea, so what did you do to that patient with a long list of allergies and a 10 out of 10 migraine? I would have just given her a pack of ice if that was her only complaint.

  7. rlbates said

    Great post! I try to explain to patients the difference between an unpleasant side effect (nausea, etc) and true allergy (hives, swelling). Some listen, some don’t.

  8. Denise said

    I have had problems with this for years. I have adverse reactions to several medications. Anxiety attacks, tachycardia, nausea, heartburn… it does very little good to tell the nurses who fill out the initial paperwork. Often it’s easier for them to put them down as allergies rather than list the adverse reactions. Several years ago I was prescribed albuterol treatments prior to surgery to clear up a respiratory problem. The pharmacy filled the prescription wrong and I was using 10 times the amount I should have been. Two major anxiety attacks later and now I can’t use it at all. This translates to allergic in some people’s minds.

  9. MonkeyGirl said

    I have an allergy to stupid. It makes me break out in twitches.

    I’ve been twitching all night tonight.

    Nothing like a Friday night when the BAL to IQ Ratio is greater than 2 to 1.

  10. Christine said

    Denise, true. Allergies are histamine induced, however, I’ve had non-histamine induced rxns to drugs I far prefer not to take. For example, any cream with benzoyl peroxide in it makes my face burn and my skin peal off. I’d definitely won’t be taking that anymore, but it’s not an allergy per say. But it is often easier to just call it an allergy than explain that benzoyl peroxide gives me second degree chemical burns.

  11. cheryl said

    I particularly love when a patient presents with the long allergy list…including things like haldol, thorazine, oxycontin, etc. but when you ask what their medical history is they deny any medical/surgical/psych history.

  12. drh said

    Trying to explain to some of these people that what they have is not an actual allergy is like trying to explain to others that their temperature of 98.6 is not an actual fever even though their “normal” temperature is 97.0. I totally agree with the more allergies=more crazy hypothesis. Scalpel, I’ve never had a single one of the migraine patients with a million allergies forget to list toradol. That’s usually toward the top of the list between ibuprofen and Imitrex!

  13. Nurse K said

    One time, I had one of these patients put on her light while getting Moxifloxacin (a drug in the only major antibiotic drug class she could “take”/had left), and she was complaining of hives and itching. She got anxious, frantic and told me to tell her what the drug was that she was getting. Low and behold, no hives. She was insistent that she had hives and that I immediately needed to stop the drug. Trouble breathing? Nope. I told her there was no indication to stop the drug because there was no rash and no trouble breathing, yet she kept insisting that there was. I got the doctor who also told her that there was no reason to stop the drug and if she still wanted us to stop it, she’d be refusing all antibiotics until she was admitted and her primary could sort it out. Of course, we offered ativan as the “cure” to her allergy, but she still refused to let the drug infuse. I DID NOT enter that drug on her allergy list because I felt it a violation of “first do no harm.” Entering that as a drug allergy would have screwed her over.

  14. drh said

    Somehow, I didn’t even see the copy of her actual list the first time I read this. That’s impressive. She really didn’t list Toradol, though I’d doubt she found that acceptable, especially given Demerol is conspicuously absent from her list. Just curious what she did let you give her!?

  15. MLO said

    I despise the people without allergies who claim to have allergies because I’m in the 1% of adults with very real multiple allergies (well over 5) and I carry my MEDICAL RECORDS with me due to this. Due to the attitude displayed here, I have ended up in very real trouble because even with my records, I have been prescribed items that cause rather dramatic reactions.

    BTW, in some patients, nausea is the immediate precursor to sudden loss of consciousness due to a sudden drop in blood pressure, aka, anaphylatic shock – swelling and hives are not necessary for a diagnosis of an IgE mediated allergy. Oh, yes, I know there is a difference between a chemical reaction and an allergic reaction. Go talk to your allergist or radiologist friends about the difference in danger depending on the type of reaction. There really isn’t much difference of the danger depending on the type of reaction.

    Do you realize how hard it is to avoid certain substances in our current drug supply? Try being allergic to corn. It is literally in everything. Luckily, I do not react to certain versions in very, very small quantities, but I know some folks who do. I have 0 tolerance of ingested ethanol (corn-based alcohol) and corn oil – both very popular in current drug formulations. Ethanol is now in ALL emergency asthma inhalers, so I’m just screwed.

    This is why I am very, very careful of the doctors I see – when I can control it. I have NEVER had a good experience in the ER. I have actually had an ER doctor actively argue with my allergist about course of treatment. The allergist, luckily, won.

    Do a search on Medline and you will find the huge number of articles showing that physicians do not take allergy seriously enough – even with life-threatening reactions. This is a world wide phenomenon.

    Please, do not override an allergist’s MEDICALLY TESTED diagnosis. You can kill someone that way.

    Pax.

  16. enrico said

    MLO: If you came in saying you had a severe corn allergy and listed known pharmaceutical products that compounded it–regardless how detailed–I’d like to believe a medical professional would take it in stride and accomodate as best as possible. I’m not jaded as jaded yet, granted, but long list with a common thread is logical.

    The loon above listing “prednisone: hives, intense itching” is as pharmacologically insane as “aspirin: clots” or “atenolol: hypertensive crisis.”

    Scalpel was 100% on the money. Barring that, I’d say just administer the drug of choice + an anti-H1 adjunct (Benadryl seemed to pose no problems) to combat the “allergy,” since all seemed to be IgE/Type1 rxs.

  17. PalMD said

    MLO, i think you need a new allergist.
    Pharmaceutical grade ethanol is a simple organic compound…it does not contain an “essence” of that from which it was distilled.
    You need to seek out a professional with a little better knowledge.

  18. lm said

    Ok – I’m a little “irritated”. I found this article after searching for answers on why dd has reacted to 4 out of 4 antibiotics. Over 50 food allergies and now has a g-tube for feeding using an medical formula that has no intack protiens.

    LISTEN UP: We are not crazy moms trying to harm our kids or get attention. We are frantic people trying to figure out why their immune system is so messed up We have had doctors tell is it is not possible (despite the eye being swollen shut or the 3″ hives on your baby). It’s all in our minds! babies don’t have allergies. Then you give my kid something they are allergic to – but you DON’T sit with them for the next 6-8 hours while they scream in severe pain, break out itching then in hives. If you are lucky their asthma won’t kick in or their face won’t swell up. If you are very, very lucky an inhaler and antihistamine will work.

    Not all allergies are IGE. Level or class of IGE response doesn’t dictate reaction level. My kiddo must have missed the memo stating “borderline allergy” means go ahead and enjoy that food!

    Say take you more than allergies = crazy, and need more attent mindset and read up. Go to sites that discuss food allergies, read up on Eosinphilic Enteropathy. Then decide how messed up your life would be to NOT HAVE ANY FOODS and have EVERYONE tell you that you are making it up and people think you are crazy for trying to procect your child because the last time they were around your child they didn’t have a major reaction. What kid EVER gets sick when it is not midnight, your home alone, and the other kids are already in bed or at the worst possible minute? In that respect my kiddo MUST be normal!

    So yeh it is rare, but it does happen! And you know what, no one believes us still!

    One fuming mom!

  19. Dr. WhiteCoat said

    LM, my kids have allergies, too. I know where you’re coming from, but you’re missing the point. No one is saying that people can’t have multiple allergies. The point is that what many people describe as “allergies” really are not allergies.
    If you had to choose between your kid having a diarrhea “allergic reaction” to his last course of Augmentin for an ear infection or possibly foregoing intravenous antibiotics that could save his life, which would you choose?
    Patients who report “diarrhea” or “headache” as an allergy scare the physicians away from using those medications to which the patient is allegedly “allergic.” I’ve had people tell me that the bad taste they get in their mouth from Biaxin is an allergic reaction. Should I not treat that patient with other medications in that class because of this? If I give the medication and there is some bad outcome, everyone comes after my head because I gave the patient a medication he was “allergic” to.
    If your kid has this many allergies, you would do yourself and him a big favor by having your physician type out a letter stating what medications he CAN take – especially the commonly used medications like antibiotics and GI meds. Bring it with you or put it on a medical alert bracelet. Good luck with him!

  20. PalMD said

    Many infants go through difficulties with intact proteins. My daughter was on neocate for many (expensive) months. These infancy protein allergies are very different from adults who simply believe that they are allergic to things that happened to make them feel bad.

  21. MLO said

    PalMD, you may not be aware of the extremely poor manufacturing practices used in the manufacture of everything these days. I know that technically, the ethanol reactions (actual reactions – as seen in an ER), are chemical reactions and not IgE reactions.

    I have never met a generalist since my one doctor whose son also had sever allergies retired that was knowledgeable enough to treat those with severe allergies. They just don’t have the knowledge as the field is incredibly complex, and unless you deal with it day-in and day-out, you aren’t going to be sensitive the problems. I realize I can’t expect a generalist to treat my allergies – but what always irks me is the number of generalists who think they know better than the allergist other allergists send their family to!

  22. Do you know the First-aid treatment for the following condition. Peanuts are nuts people all over the world love eating. Though predominantly used in the manufacture of peanut butter, peanuts are today one of the most allergenic foods available. They are today found in lots of food products directly or indirectly. Food labels labeled with ‘hydrolyzed vegetable protein’ or ‘groundnuts’ usually contain peanuts which can prove to be life threatening to those having allergic reactions to peanuts.

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